Luigi Zecca

The paper uses iPSC-derived microglia from BPAN patients to identify immune-related alterations and immunomodulatory signaling changes, revealing a shift to a reactive, disease-associated state.

This study shows that synthetic neuromelanin induces inflammation and may contribute to dopaminergic neuron degeneration in a new mouse model of Parkinson's disease.

This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.

This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.