Author

W. Frank Lenoir

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-7413-1885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:CRISPR screen· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Medina ColiciD· 3 shared Traver HartiD· 3 shared Eiru KimiD· 2 shared Gang WangiD· 2 shared Megan McLaughlin· 2 shared Merve DedeiD· 2 shared Annabel K Sangree· 1 shared Audrey L GriffithiD· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenetics

Medina ColicORCID

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Author profile →

4 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 8, 2020

Discovery of novel putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in AML cells

W. Frank Lenoir, Micaela Morgado, Peter C DeWeirdt…·Traver Hart

The paper identifies novel tumor suppressors from CRISPR screens and reveals rewired lipid metabolism in AML cells through functional analysis of gene modules.

DOI 10.1101/2020.10.08.332023

humanCRISPR screen

𝕏 PostBluesky

Systems BiologyLife Science AlliancePeer-reviewedApr 1, 2019

Hierarchical organization of the human cell from a cancer coessentiality network

Eiru Kim, Merve Dede, W. Frank Lenoir…·Traver Hart

The paper constructs a coessentiality network from CRISPR knockout screens to infer gene function and reveal hierarchical cell organization.

90 citationstop 4%

humanCRISPR screen

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BioinformaticsbioRxivPreprintMar 11, 2019

Identifying chemogenetic interactions from CRISPR knockout screens with drugZ

Medina Colic, Gang Wang, Michal Zimmermann…·Traver Hart

drugZ identifies chemogenetic interactions from CRISPR screens, finding more homologous recombination repair pathway genes and confirming KEAP1 loss as a resistance factor for ERK inhibitors.

17 citations

humanCRISPR screen

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BioinformaticsScientific ReportsPeer-reviewedApr 18, 2017

The E. coli molecular phenotype under different growth conditions

Mehmet Umut Caglar, John R. Houser, Craig S. Barnhart…·Claus O. Wilke

This study presents a comprehensive transcriptomics and proteomics dataset of E. coli under 34 growth conditions, revealing differences between exponential and stationary phases and differential gene expression under specific stresses.

66 citations

E. colibulk RNA-seq

𝕏 PostBluesky