Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level Regulation
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel Joseph Reiter
The paper identifies a network of 26 genes at the intersection of melatonin signaling and phase separation, showing melatonin suppresses oncogenic drivers and correlates with poorer survival in breast and gastric cancers.