Gonzalo G. Guendulain

This study identifies a critical technical limitation in SP-IRIS/IF platforms where non-vesicular artifacts persist after detergent treatment, highlighting the need for detergent lysis controls to ensure accurate single-EV phenotyping.

The paper shows human neural rosettes secrete extracellular vesicles containing neuronal and glial components that influence hiPSCs morphology and reduce SOX2 expression.