BiochemistrybioRxivPreprint
Time-resolved ligand dynamics revealed in a β-lactamase using room-temperature serial crystallography
Philip Hinchliffe, Catherine L. Tooke, Michael Beer…·JAMES M. SPENCER
This study uses room-temperature serial crystallography to observe time-dependent ligand dynamics of the β-lactamase CTX-M-15 with avibactam, revealing conformational changes critical for inhibitor reformation.
DOI 10.64898/2025.12.17.692331