Author

Margaret K. Shirra

University of PittsburghORCID 0000-0002-7526-1665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Karen M. ArndtiD· 4 shared Mitchell A. EllisoniD· 2 shared A Elizabeth HildrethiD· 1 shared Brendan M. McShaneiD· 1 shared Christine E. CucinottaiD· 1 shared Eleanor M. Kerr· 1 shared Fei Fang· 1 shared Hannah G. Marvil· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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10 top collaborators · 19 mutual co-author links

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4 shared papersMolecular Biology

Karen M. ArndtORCID

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4 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedAug 6, 2025

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes

Sarah A. Tripplehorn, Santana M. Lardo, Margaret K. Shirra…·Karen M. Arndt

10 citations

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMay 4, 2022

Spt6 directly interacts with Cdc73 and is required for Paf1C recruitment to active genes

Mitchell A. Ellison, Matthew S Blacksmith, Sanchirmaa Namjilsuren…·Karen M. Arndt

The paper identifies a direct interaction between Cdc73 and Spt6, showing Spt6 is required for Paf1C recruitment to active genes in yeast.

1 citation

yeastexperimental assay

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Molecular BiologyG3 Genes Genomes GeneticsPeer-reviewedAug 31, 2021

Opposing functions of the Hda1 complex and histone H2B mono-ubiquitylation in regulating cryptic transcription initiation in Saccharomyces cerevisiae

Margaret K. Shirra, Rachel A. Kocik, Mitchell A. Ellison, Karen M. Arndt

The paper identifies a genetic interaction between the Hda1C histone deacetylase and the H2B ubiquitylation pathway in regulating chromatin structure during transcription elongation in yeast.

5 citations

yeaststatistical model

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Molecular BiologyNucleic Acids ResearchPeer-reviewedJun 11, 2019

The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo

Christine E. Cucinotta, A Elizabeth Hildreth, Brendan M. McShane…·Karen M. Arndt

The paper identifies direct interactions between the nucleosome acidic patch and Paf1 and FACT complex subunits, showing their role in chromatin architecture and transcription elongation.

33 citations

𝕏 PostBluesky