Author

Samy Kefalopoulou

Royal Netherlands Academy of Arts and SciencesORCID 0000-0002-7565-9614Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:ChIP-seq· 4 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Allen WangiD· 2 shared Bing ReniD· 2 shared Jinzhao WangiD· 2 shared Jop KindiD· 2 shared Joshua ChiouiD· 2 shared Kyle J. GaultoniD· 2 shared Maike SanderiD· 2 shared Ryan J. GeusziD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Allen WangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

GenomicsNature Cell BiologyPeer-reviewedJul 1, 2025

Time-resolved and multifactorial profiling in single cells resolves the order of heterochromatin formation events during X-chromosome inactivation

Samy Kefalopoulou, Pim M. J. Rullens, Kim L. de Luca…·Jop Kind

The paper introduces Dam&ChIC, a method for time-resolved chromatin profiling in single cells, revealing that genome-lamina detachment precedes H3K27me3 accumulation during X-chromosome inactivation.

13 citations

humanChIP-seq

𝕏 PostBluesky

Developmental BiologybioRxivPreprintMay 5, 2025

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Konrad Chudzik, Isabel Misteli Guerreiro, Samy Kefalopoulou…·Michael I. Robson

The paper shows that genome-lamina interactions are reconfigured during limb development to prime regulatory domains for gene activation and support cell-fate decisions.

2 citations

mouseChIP-seq

𝕏 PostBluesky

GenomicseLifePeer-reviewedFeb 5, 2021

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Ryan J. Geusz, Allen Wang, Joshua Chiou…·Maike Sander

The paper identifies T2D risk variants in pancreatic progenitor-specific enhancers and shows their role in regulating developmental genes involved in pancreas morphogenesis.

26 citationstop 4%

humanzebrafish

𝕏 PostBluesky

GenomicsbioRxivPreprintAug 28, 2020

A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

Ryan J. Geusz, Allen Wang, Dieter K. Lam…·Maike Sander

The paper shows FOXA pioneer factors prime some enhancers but require lineage-specific TFs to activate others, influencing endodermal organ fate decisions.

2 citations

humanChIP-seq

𝕏 PostBluesky