Patricia A. Fitzgerald-Bocarsly

The paper identifies a senescence-like transitional state in aging human monocytes driven by AP-1, leading to inflammatory monocyte expansion and systemic inflammation.

This study identifies epigenetic regulators of CD8+ T cell senescence in aging humans using multiomic profiling and shows their relevance to disease progression.

This study identifies senescent CD8+ T effector memory cells as functionally impaired and enriched in aging and disease, and shows they hinder immunotherapy responses.

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.