Yeara Jo

This study identifies ITPKB as a regulator of NK cell desensitization, showing its inhibition enhances antitumor immunity in murine and human models.

This study shows that delivering cGAMP via bacteriophage MS2 nanoparticles enhances STING activation and antitumor immunity in mice.

Intra-tumoral Treg ablation enhances NK cell-mediated tumor control by restoring IL-2 production, effective against both MHC I+ and MHC I- cancers without systemic toxicity.

This study investigates how viral infection affects DC progenitor development, finding that glucocorticoids suppress pDC generation by altering transcriptional and epigenetic programs.

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

The paper investigates enhancer activity's role in random monoallelic expression (RME) of NK cell receptor genes, finding that enhancer properties drive RME and suggest it is a general phenomenon.