Cancer BiologybioRxivPreprint
Primary cilia promote resistance to EGFR tyrosine kinase inhibitor, osimertinib, in non-small cell lung cancer
Li Wang, Anuradha Pandit, Sk. Kayum Alam…·Luke H. Hoeppner
This study shows that primary cilia formation contributes to resistance to osimertinib in EGFR-mutated NSCLC by promoting sodium influx and HDAC6 inactivity, and that targeting ciliogenesis can reverse resistance.
DOI 10.64898/2026.03.03.709408