Yuyang Zhang

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

This paper introduces TopoDiff, a diffusion-based framework for protein backbone generation that improves global geometry control and fold diversity through a structure encoder and latent sampler.

TopoDiff improves protein backbone generation by using a topology-aware latent encoding to enhance controllability and coverage of generated structures.