Author

Uri R. Mbonye

Case Western Reserve UniversityORCID 0000-0002-7694-0803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Jonathan KarniD· 2 shared Amie DonneriD· 1 shared Ana BellomoiD· 1 shared Eleonora ElhalemiD· 1 shared Konstantin LeskoviD· 1 shared Lucía Gandolfi DonadioiD· 1 shared Maria Julieta CominiD· 1 shared Meenakshi Shukla· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Jonathan KarnORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 15, 2026

RasGRP1 agonists stimulate P-TEFb biogenesis via MEK-ERK-mTORC1 signaling to reverse HIV latency with minimal CD4 downregulation

Uri R. Mbonye, Ana Bellomo, Eleonora Elhalem…·Jonathan Karn

DOI 10.64898/2026.01.14.699500

humanproteomics

𝕏 PostBluesky

Molecular BiologyPLoS PathogensPeer-reviewedSep 16, 2021

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

Uri R. Mbonye, Konstantin Leskov, Meenakshi Shukla…·Jonathan Karn

This study identifies PKC-independent signaling pathways that reactivate HIV latency by regulating P-TEFb availability in CD4+ T cells.

26 citations

humanbulk RNA-seq

𝕏 PostBluesky