Simon Ekström

The paper maps the structural epitope landscape of pneumolysin and identifies a conserved cross-species neutralising site among cholesterol-dependent cytolysins.

This study shows that PARP15's ADP-ribosyltransferase activity is regulated by dimerization, with dimers required for catalytic function and monomers inactive.

This study identifies SpnA's role in inhibiting the complement system by interacting with C5b67, preventing membrane attack complex assembly.

This paper designs an epitope-centric nanoparticle vaccine against Streptococcus pyogenes using structural mass spectrometry and deep learning to enhance immunogenicity.

This study shows that streptolysin O enhances plasminogen to plasmin conversion by interacting with plasminogen and altering its conformation to increase sensitivity to proteolytic processing.

This study uses multi-modal mass spectrometry to identify a conserved protective epitope in Streptolysin O from S. pyogenes, which could inform vaccine and therapeutic development.