Yenan T. Bryceson

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

This study shows that ISG15-USP18 signaling limits viperin-dependent metabolic antiviral restriction by stabilizing USP18 and reducing viperin expression, thereby inhibiting viral replication.

This study identifies dysregulated antibody-mediated cellular responses in MIS-C, linking NK cell dysfunction to immune pathology and suggesting potential therapeutic interventions.

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.

DEPECHE is a clustering algorithm that improves interpretability of single-cell data by retaining only relevant variables for cluster separation.