Surabhi Chowdhary

The paper shows that chaperone condensates specifically buffer the heat shock response, setting activation thresholds and ensuring specificity to heat shock in budding yeast.

The paper shows transcriptional condensates form stepwise in yeast to enable graded and 3D gene control during heat shock response.

This study identifies inducible transcriptional condensates in yeast heat shock response and shows they drive 3D genome reorganization through Hsf1-mediated gene coalescence.

This study shows that Hsf1 drives intergenic interactions of HSP gene loci in yeast during heat shock, forming subnuclear foci that dissolve with transcriptional attenuation.