Ulrike Fischer

The paper shows re-replication is a physiological mechanism in human stem cell differentiation, increasing gene copy numbers to meet protein demands during differentiation.

The paper investigates gene amplification dynamics during chondrogenic differentiation of human mesenchymal stem cells and finds that amplifications are transient and stage-specific, correlating with proteoglycan deposition patterns.

The paper identifies age-related miRNA deregulation patterns in aging rhesus macaques, highlighting tissue and sex-specific changes and cross-species conservation.

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.