Adib Keikhosravi

The paper identifies DNA replication machinery components as critical for TAD boundary re-establishment during DNA replication.

The paper investigates the relationship between TAD boundaries and gene activity using single-cell imaging, finding they are largely uncoupled.

The paper identifies molecular regulators of centromere distribution by screening nuclear proteins and shows that mitosis influences interphase genome organization.

OptoLoop enables light-induced manipulation of chromatin contacts to study genome organization's role in gene regulation, showing looping-mediated repression of TERT.

The paper shows that mechano-osmotic changes in pluripotent stem cells influence chromatin state and fate transitions by integrating mechanical and biochemical signals.

The paper develops a framework to quantitatively analyze spatial centromere distribution patterns using clustering metrics and modeling techniques, identifying Ripleys K Score as the most accurate metric.

The paper develops high-throughput DNA/RNA FISH methods to visualize allele-level chromatin features and gene activity across cell populations.

HiTIPS provides a flexible, open-source platform for high-throughput image analysis in cell biology, supporting customization and integration of new algorithms for tasks like segmentation, tracking, and quantification.