Adam G. Chatoff

This study investigates the metabolic and epigenetic changes in SDH-deficient cells and tumors, finding increased succinyl-CoA but no corresponding increase in histone succinylation or significant effects from desuccinylase inhibition.

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.