NeurosciencebioRxivPreprint
Chronic administration of a positive allosteric modulator at the alpha5-GABAA receptor reverses age-related dendritic shrinkage
Thomas D. Prévot, Akiko Sumitomo, Toshifumi Tomoda…·Etienne L. Sibille
This study shows that chronic treatment with a 5-GABA-A receptor PAM increases dendritic length, spine count, and density in mice, suggesting potential for reversing age-related cognitive decline.
DOI 10.1101/2020.02.28.964742