Sebastiaan H. Meijsing

The paper quantifies enhancer activity dynamics in mESCs during differentiation using FAIRE-STARR-seq, identifying features that predict enhancer activity and reveal regulatory insights.

The paper shows that glucocorticoid receptor activation leads to reversible chromatin changes and gene-specific transcriptional memory in human airway epithelial cells.

This study identifies mechanisms by which androgen and glucocorticoid receptors achieve functional diversification through distinct DNA binding and downstream regulatory events.

CRUP predicts condition-specific regulatory units by analyzing histone modification ChIP-seq data and linking enhancers to target genes in rheumatoid arthritis.

This study develops synSTARR-seq to analyze how DNA sequence and shape affect transcriptional activity and noise using synthetic GR binding sites.