Pierre Millard

The paper introduces the concept of the cellular electron economy to quantify and organize electron flow across metabolism in microorganisms, revealing how carbon sources and electron disposal capacity shape metabolic organization.

This paper demonstrates that heterologous Pdu BMCs in E. coli can metabolize a broader range of diols and triols than previously known, including glycerol and up to 1,2-pentanediol, and shows their potential for biotechnological applications.

This paper shows acetate helps Escherichia coli adapt to nutrient changes by reducing lag time and replenishing metabolic pools.

MultiNMRFit is a software tool for analyzing NMR spectra to extract signal parameters, offering flexibility and robustness in metabolomics and isotope labeling studies.

The paper introduces dynafluxr, a method to estimate metabolic flux dynamics from metabolite concentration time courses using constrained B-splines, showing it works well on both simulated and experimental data.

This study shows acetate can boost bioproduction in glucose-grown E. coli by reducing carbon loss, increasing acetyl-CoA levels, and improving biomass accumulation, validated for mevalonate and 3-hydroxypropionate.

The paper develops a method to measure enzymatic parameters in vivo using synthetic biology tools and applies it to study carotenoid pathway enzymes in yeast.

PhysioFit quantifies cell growth parameters and extracellular fluxes using flexible growth models and provides a user-friendly software tool for non-computational biologists.

This study characterizes the ethanolamine utilization BMC in E. coli using genetic, omics, and modeling approaches, revealing ethanolamine as a dual carbon and nitrogen source.

This paper shows that 6-phosphogluconolactonase is essential for efficient oxPPP function in E. coli, as its absence is compensated by an extracellular bypass pathway.

This study shows acetate enhances Escherichia coli growth by compensating for reduced glycolytic flux through co-utilization with glucose.

IsoSolve integrates isotopic measurements from MS and NMR to improve isotopic coverage and consolidate data for metabolic network analysis.

This study develops a kinetic model of E. coli metabolism to explain acetate overflow, showing acetate regulates glucose metabolism and is not a wasteful by-product.

ScalaFlux quantifies metabolic fluxes in subnetworks without requiring external network information, validated on yeast mutants and simulated data.

Interact automates analysis of 1D and 2D NMR titration experiments to quantify protein-ligand interactions through peak picking, annotation, and fitting procedures.