Louis R. Lapierre

This study shows that XPO1 inhibitor KPT-330 improves spatial memory in Alzheimer's 5XFAD mice by reducing amyloid deposition in specific brain regions while increasing overall amyloid levels.

This study reanalyzes proteostasis in C. elegans and finds that polyubiquitinated protein levels remain constant with age, contradicting a previous conclusion.

AltumAge is a deep learning-based DNA methylation clock that improves age prediction accuracy and interpretability across tissues and ages.

This study shows neuronal HLH-30/TFEB improves thermoresistance in C. elegans by inducing mitochondrial fragmentation in muscles, independent of DAF-16/FOXO.