Loris Rizzello

This paper develops a vesicle-based CRISPR/Cas9 platform for efficient gene knockout in primary human myeloid cells, preserving viability and enabling downstream functional studies.

The paper identifies IL-10-producing pre-Th17 cells in AD-HIES patients that respond to pathogens and support IgE production despite STAT3 mutations.

This study identifies a mechanical regulation pathway involving Src-FAK-AMPK-GBF1 that controls cargo sorting and secretion from the Golgi in response to substrate stiffness.

This study shows that chronic Mycobacterium abscessus infection causes macrophage senescence, leading to pro-inflammatory cytokine secretion and secondary senescence in neighboring cells.

This study demonstrates that Ms6LysB can impair M. tuberculosis growth and retain lytic properties when internalized by macrophages, suggesting its potential as a new therapeutic strategy.

This study investigates how LRP1 mediates transport across blood-brain barrier endothelial cells, showing that ligand avidity influences cargo sorting and trafficking mechanisms.

This paper demonstrates the targeting and intracellular delivery of antibiotics to mononuclear phagocytes to eradicate intracellular parasites like Mycobacterium tuberculosis.