Oliver Gorka

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

This study shows NEK7 accelerates NLRP3 inflammasome activation but is not essential, suggesting potential limitations in targeting this interaction for drug development.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

This paper identifies vacuolar disruption as a trigger for NLRP3 inflammasome activation in Toxoplasma gondii infection and shows ROP5 and ROP18 inhibit IL-1β release by protecting the parasitophorous vacuole and interacting with GBP5.