Rainer Lehtonen

GenomeSpy is a grammar-based visualization toolkit for genomic data analysis that enables interactive exploration of large datasets, demonstrated on ovarian cancer samples.

PRISM recovers cell type specific expression profiles from composite RNA-seq data, improving patient response prediction compared to raw bulk data.

This study identifies epigenetic inhibitors that enhance the effectiveness of immunochemotherapy in DLBCL by disrupting DNA repair and cell cycle pathways.

The paper presents a computational method to identify differentially methylated sites in heterogeneous tumor samples with varying cancer cell fractions, without needing normal controls or prior purity estimates.

This study identifies five new genetic loci associated with uterine leiomyoma risk and links them to estrogen receptor alpha and genetic stability.