Patrick Petzsch

This study uses patient-derived iPSCs to model a MIC13 variant causing mitochondrial liver disease, revealing metabolic defects and early fibrosis through multi-omics analysis.

This study identifies Hox4/5 and Hox6/7 genes' roles in forelimb positioning through loss- and gain-of-function experiments in chick embryos, showing Hox4/5 provide permissive cues and Hox6/7 determine limb position.

This paper develops a mouse model of diabetes-induced heart failure with preserved ejection fraction (HFpEF) by combining high-fat, high-sucrose diet and streptozotocin, showing distinct metabolic and cardiac changes compared to other HFpEF models.

The paper shows MIC26 regulates metabolic pathways by modulating mitochondrial metabolite exchange, with its role reversing under hyperglycemia.

The paper shows BATF suppresses IFN I production in pDCs via DC-SCRIPT, revealing a negative feedback loop in antiviral immunity.

This study characterizes the transcription factor reservoir and chromatin landscape in naive and TLR9-activated plasmacytoid dendritic cells across multiple timepoints.