Zi Hao Liu

IDPForge generates all-atom ensembles of intrinsically disordered proteins and regions using a transformer diffusion model, showing good agreement with experimental data.

The paper generates conformational ensembles of the 4E-BP2:eIF4E complex using smFRET and NMR data, revealing dynamic structural changes and new contact regions.

The paper investigates how competing factors in biomolecular condensates modulate the rate of poly(A) RNA deadenylation by CNOT7, revealing concentration-dependent increases and diffusion-related decreases in enzymatic efficiency.

This study identifies PRRC2A, PRRC2B, and PRRC2C as stress granule proteins that regulate translation by interacting with the eIF3 complex and 48S PIC factors.

The paper introduces FELS, a method to screen free energy landscapes for disordered proteins, and applies it to tropoelastin, revealing its conformational ensemble and resolving conflicting models.

The paper combines NMR data with AlphaFlow to identify excited state conformers of pro-IL-18, revealing structural insights from transient states.

AlphaFlex generates atomistic conformational ensembles for human proteins with intrinsically disordered regions, integrating AlphaFold models and implicit bilayers for transmembrane proteins.