BiochemistryACS Chemical BiologyPeer-reviewed
Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability
Jesse Coker, Rong Sun, Paul M. Polzer…·Shaun R. Stauffer
The paper identifies false positive inhibitors of NSP14 ExoN due to contaminating divalent cations, highlighting challenges in fragment-based drug development for this target.
DOI 10.1021/acschembio.5c00930