Author

Jae Seung Lee

University of PennsylvaniaORCID 0000-0002-8421-3155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sara R. CherryiD· 2 shared Arjun RustagiiD· 1 shared Bonsu KuiD· 1 shared Catherine A. BlishiD· 1 shared Chonsaeng Kim· 1 shared D. C. SchultziD· 1 shared Dae‐Gyun AhniD· 1 shared Do Yeon KimiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

Sara R. CherryORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 28, 2026

Distinct virus-derived circular RNA molecule influences host response during SARS-CoV-2 infection

Elysse N. Grossi-Soyster, Rebekah C. Gullberg, Arjun Rustagi…·Peter Sarnow

The paper identifies a novel SARS-CoV-2-derived circular RNA, circ7b8N, which modulates host gene expression and is detectable in clinical samples, suggesting a role in host-pathogen interactions.

DOI 10.64898/2026.04.28.721328

humanbulk RNA-seq

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MicrobiologybioRxivPreprintJan 29, 2026

De novo design of a safe and potent respiratory syncytial virus immuno-focusing antigen

Woo Yeon Hwang, Jinung Song, Jiwon Choe…·Young‐Chan Kwon

This study designs a de novo RSV antigen using AI to reduce immunopathology while maintaining immunogenicity, showing safety and efficacy in preclinical models.

DOI 10.64898/2026.01.28.702448

mousenon-human primate

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MicrobiologyCell ReportsPeer-reviewedDec 20, 2024

Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy.

Jae Seung Lee, Mark Dittmar, Jesse Miller…·Sara R. Cherry

This study identifies how SARS-CoV-2 evolves to counteract host interferon signaling through interactions with autophagy pathways.

21 citations

humanexperimental assay

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