Jose Henrique Pereira

This paper designs novel Rubisco variants using protein language models, identifying active candidates with improved CO2/O2 specificity and structural validity.

The paper characterizes the structural and functional diversity of rubisco by synthesizing and analyzing diverse sequences, revealing a dimeric origin and a novel large rubisco structure.

The paper characterizes two GT61 enzymes in Sorghum bicolor, identifies their functions in xylan modification, and identifies a residue critical for sugar donor specificity through structural and biochemical analysis.

This paper introduces a modular polyketide synthase platform for producing diols, amino alcohols, and hydroxyacids using engineered Streptomyces albus strains.

The paper identifies a putative rhamnogalacturonan-II CMP-β-Kdo transferase by using CRISPR/Cas9 to generate a callus mutant lacking Kdo, which disrupts RG-II crosslinking and growth.

The paper introduces a 3-track network for accurate protein structure and interaction prediction, achieving performance close to DeepMind's CASP14 results and enabling rapid modeling of protein complexes from sequence data.

The paper identifies an iron-dependent enzyme in plants that completes the lysine catabolism pathway, showing structural and functional conservation across species.