Cancer BiologyThe EMBO JournalPeer-reviewed
Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling
Krzysztof Wierbiłowicz, Chunsong Yang, Ahmed Almaghasilah…·Bryce M. Paschal
The paper identifies PARP7 as an enzyme that ADP-ribosylates the androgen receptor, marking it for degradation and creating negative feedback on AR-dependent gene expression.
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