Olle Korsgren

This study maps spatial and functional states of human pancreatic cells in health and disease using combined single-cell and spatial transcriptomics with calcium imaging.

The paper performs single-cell proteomics on pancreatic islets from healthy and T1DM donors, identifying cell type-specific differences and donor-specific features.

This study uses 3D optical imaging to show that extra-islet β-cells are more preserved in late-onset Type 1 Diabetes compared to islet-associated β-cells.

The paper uses 3D imaging to reveal new heterogeneity in human pancreatic islets, showing 50% lack glucagon-producing cells.

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.