W. Matthew Michael

This paper shows DNA-PKcs phosphorylates TOPBP1 at S1131 to activate ATR at DSBs independently of ATM and NHEJ.

The paper shows that HRDE-1 and NRDE-3 sequentially contribute to H3K9me3 hyperdeposition in C. elegans PGCs during starvation, leading to transcriptional silencing.

The paper analyzes the transcriptome of C. elegans early embryos depleted of TOP-2 and CAPG-2, identifying 144 upregulated and 172 downregulated genes, with upregulated genes predominantly somatic.

The paper investigates genome silencing mechanisms in C. elegans germline specification, finding that condensin II/TOP-2 and PIE-1 redundantly repress transcription in early embryos, while H3K9me is not required.

This study identifies three molecular systems required for transcriptional silencing in C. elegans oocytes and links PIE-1 nucleolar residency to its repressive function.