Author

Denise Minerva Drotar

University of Florida HealthORCID 0000-0002-8538-6875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Mark A. AtkinsoniD· 3 shared Amanda L. PosgaiiD· 2 shared Clive Henry WasserfalliD· 2 shared Edward A. PhelpsiD· 2 shared MacKenzie D. WilliamsiD· 2 shared Maigan A. BruskoiD· 2 shared Todd M. BruskoiD· 2 shared Alexandra E. CuaycaliD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBioengineering

Mark A. AtkinsonORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintOct 21, 2025

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

Matthew W. Becker, Matthew E. Brown, Katherine Wiseman…·Edward A. Phelps

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

DOI 10.1101/2025.10.21.683528

humanproteomics

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ImmunologybioRxivPreprintMar 5, 2025

Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata

Nathan Steenbuck, Nicolas Damond, Stefanie Engler…·Bernd Bodenmiller

The paper uses imaging mass cytometry to analyze human pancreatic samples and identifies early β-cell dysfunction and immune changes in type 1 diabetes progression.

3 citations

humanimaging

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PathologyCell ReportsPeer-reviewedJun 1, 2024

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

Denise Minerva Drotar, Ana Karen Mojica-Avila, Drew T. Bloss…·Mark A. Atkinson

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

14 citations

humanproteomics

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