Sean R. Cutler

This study identifies MpSDR4 in liverworts as a regulator of abscisic acid sensitivity and gemma cup growth, shedding light on the evolutionary divergence of SDR4 function in plant reproduction.

The paper engineers a genetically encoded biosensor, PYRNSAID, to detect profen NSAIDs in wastewater with nanomolar sensitivity and demonstrates its functionality in simulated wastewater matrices.

The paper designs dynamic biosensors for detecting nitazenes and their metabolites using computational methods, achieving low nanomolar detection limits and limited cross-reactivity.

The paper identifies small-molecule sensors using ABA receptors and demonstrates their ability to detect diverse ligands including plant natural products and synthetic chemicals.

The paper designs and engineers minimal protein-based molecular inverters and switches that respond to ligands, demonstrating tunable and modular control of post-translational signaling.

This study shows that Antabactin, an ABA receptor antagonist, reduces thermoinhibition in lettuce seeds at high temperatures, improving germination rates when combined with seed priming.

The paper uses a PYR1 biosensor-driven CRISPR screen in Kluyveromyces marxianus to identify gene knockouts that enhance geraniol production by up to 2-fold.

This study analyzes two engineered biosensors based on PYR1 to recognize different ligands, revealing binding mechanisms and computational methods for biosensor design.

The paper introduces SPENCER, a high-throughput phenotyping platform for seed germination analysis, and investigates the roles of DOG1 and ABA in germination uniformity and dormancy in Arabidopsis.

The paper identifies 5 stabilizing mutations for PYR1 variants using GMMA that increase thermal stability without affecting functionality across different ligand-binding capabilities.

The paper systematically characterizes gene function in a photosynthetic organism by analyzing mutant phenotypes across diverse conditions and linking them to functional pathways.