Subhayan Chattopadhyay

This study compares mitotic and chronological epigenetic clocks in cancer, showing mitotic age is consistently advanced in adult tumors while chronological age varies by cancer type and is not linked to methylation heterogeneity.

The paper quantifies cell dynamics and interactions in neuroblastoma cell cultures under stress, finding that cell-to-cell interactions drive phenotypic adaptation, which accelerates with lower nutrient levels.

This paper develops a semi-supervised algorithm to deconvolve clonal variants in tumors, accounting for tumor cell fraction and copy number changes across samples.