William C. Forrester

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

This paper introduces a method to assess E3 ligase activity against neo-substrates using electrophilic probes, demonstrating its effectiveness with VHL and SPSB2.

This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.