NeurosciencebioRxivPreprint
Modulation of Karyopherin Levels Attenuates Mutant Ataxin-1-Induced Neurodegeneration
Elena K. Ruff, Dylan Lawrence Timperman, Adulfo Anaya Amador…·Ismael Al‐Ramahi
This study shows that increasing KPNA levels reduces mutant Ataxin-1-induced neurodegeneration by retaining it in the cytoplasm and decreasing its nuclear accumulation.