Author

Quinn T. Cowan

Gladstone InstitutesORCID 0000-0002-8697-8178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Bruce R. ConkliniD· 2 shared Grace D. RameyiD· 2 shared Hannah L. Watry· 2 shared John A. CapraiD· 2 shared Luke M. JudgeiD· 2 shared Abin AbrahamiD· 1 shared Akshita Saxena· 1 shared Bazilco M.J. Simon· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Bruce R. ConklinORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintMar 27, 2026

Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles

Grace D. Ramey, Quinn T. Cowan, Akshita Saxena…·John A. Capra

This paper identifies therapeutic opportunities for over 500 genes with dominant and dispensable disease alleles by enabling mutation-agnostic gene therapy through allele-specific targeting.

DOI 10.64898/2026.03.26.26349431

humanexperimental assay

𝕏 PostBluesky

GeneticsMolecular TherapyPeer-reviewedNov 20, 2025

Haplotype editing with CRISPR/Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL

Poorvi H. Dua, Bazilco M.J. Simon, Chiara B.E. Marley…·Luke M. Judge

This paper demonstrates haplotype editing with CRISPR/Cas9 to target NEFL missense mutations in iPSC-derived motor neurons, showing therapeutic potential and challenges in disrupting mutant allele expression.

1 citation

humanCRISPR screen

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