Dragony Fu

This study identifies biallelic TRMT1 variants causing a syndromic neurodevelopmental disorder through tRNA modification defects in humans and zebrafish.

The paper identifies the roles of TRMT1 and TRMT1L in tRNA modifications, showing their impact on tRNA stability and function, and links TRMT1 variants to disease.

This study shows ALKBH8 regulates synaptic formation and memory via redox homeostasis in Drosophila by modulating selenoprotein synthesis and oxidative stress.

This study shows that SARS-CoV-2 main protease Nsp5 cleaves and inactivates TRMT1, a host tRNA modification enzyme, leading to reduced tRNA modifications and viral RNA levels in infected cells.

The paper identifies a DALRD3 missense variant causing epileptic encephalopathy by impairing tRNA modification function.

This study investigates how 3-methylcytosine modification at position 32 of tRNA-Arg-UCU affects the structure of the anticodon stem loop and its functional implications.

The paper identifies TRMT9B as a negative regulator of synaptogenesis in Drosophila through genetic screening and biochemical analysis.

This study identifies METTL8 as the enzyme responsible for 3-methylcytosine modification in human mitochondrial tRNAs and shows its role in tRNA folding.

This study identifies a missense variant in TRMT1 causing intellectual disability by disrupting tRNA m2,2G modification.

This study identifies a complex between METTL2 and DALRD3 that catalyzes 3-methylcytosine formation in specific arginine tRNA isoacceptors and shows DALRD3 deficiency leads to loss of this modification.

This study shows that a mutation in ADAT3, linked to intellectual disability, disrupts tRNA wobble inosine formation and ADAT2/ADAT3 complex function.

This paper introduces a method using gamma-toxin endonuclease to detect mcm5s2U modification in eukaryotic tRNAs and shows its conservation across species.