O. H. Samuli Ollila

The paper identifies a native inhibitor, TrI9, from Trichoderma reesei that suppresses protease activity, improving recombinant protein production by reducing proteolysis without compromising strain fitness.

ActSeekN improves enzyme function annotation by using structural motifs from AlphaFold and UniProt data, outperforming existing methods in yeast, human, and Trichoderma reesei proteomes.

This paper investigates peptide nanodisc structure and dynamics using NMR, SAS, and MD simulations, revealing polydispersity, helical configuration, and lipid-rotation insights.

prosECCo75 improves MD simulations by incorporating electronic polarization, enhancing accuracy in modeling electrostatic interactions in biological systems without increasing computational cost.

This study evaluates polarizable lipid force fields against experimental data and finds non-polarizable models often perform better despite higher computational cost.

The paper benchmarks MD models of phospholipid bilayers against NMR data, finding that CHARMM36 and Slipids better capture conformational dynamics than other force fields.