GenomicsBioinformaticsPeer-reviewed
Deconvolution of Expression for Nascent RNA Sequencing Data (DENR) Highlights Pre-RNA Isoform Diversity in Human Cells
11 citations
Author
Noah Dukler
Cold Spring Harbor LaboratoryORCID 0000-0002-8739-8052Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2017-2021 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 34 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- GenomicsBMC BiologyPeer-reviewed
Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data
Amit Blumberg, Yixin Zhao, Yi-Fei Huang…·Adam C. Siepel
The paper introduces a method to estimate RNA half-lives using PRO-seq and RNA-seq data, finding correlations between RNA stability and splicing, miRNA binding, DNA methylation, and histone modifications.
66 citationstop 5% - GenomicsNature Ecology & EvolutionPeer-reviewed
Natural Selection has Shaped Coding and Non-coding Transcription in Primate CD4+ T-cells
Charles G. Danko, Lauren A. Choate, Brooke A. Marks…·Adam C. Siepel
The paper compares nascent transcription in primates to identify evolutionary patterns in coding and non-coding transcription, finding that transcription factor binding sites and adaptive substitutions drive species-specific differences.
- GenomicsGenome ResearchPeer-reviewed
Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol
Noah Dukler, Gregory T. Booth, Yi-Fei Huang…·Adam C. Siepel
This study uses PRO-seq to analyze the rapid transcriptional response to celastrol in K562 cells, revealing two waves of transcriptional changes and identifying key transcription factors involved.
46 citations