Author

Patrick C. Beardslee

University of DelawareORCID 0000-0002-8847-3333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Assay:proteomics· 1

Frequent Co-Authors

Karl R. SchmitziD· 2 shared Christopher J. Presloid· 1 shared Henry R. AndersoniD· 1 shared Jialiu Jiang· 1 shared Pratistha KandeliD· 1 shared Thomas M. Swayne· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

Karl R. SchmitzORCID

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2 papers

Recent·Most cited

BiochemistryMolecular MicrobiologyPeer-reviewedDec 3, 2024

ClpS directs degradation of primary N-end rule substrates in Mycolicibacterium smegmatis

Christopher J. Presloid, Jialiu Jiang, Pratistha Kandel…·Karl R. Schmitz

This study identifies ClpS as a key regulator of primary N-end rule proteolysis in Mycolicibacterium smegmatis, showing it binds canonical N-degrons and enhances substrate specificity for ClpC1P1P2 protease.

5 citations

bacteria (other)experimental assay

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BiochemistrybioRxivPreprintJan 29, 2024

Toxin-based screening of C-terminal tags in Escherichia coli reveals the exceptional potency of ssrA-like degrons

Patrick C. Beardslee, Karl R. Schmitz

The paper screens C-terminal pentapeptide sequences in E. coli to identify potent proteolytic degrons, finding that ssrA-like tags are highly effective and selectively recognized by ClpXP proteases.

DOI 10.1101/2024.01.29.576913

E. coliproteomics

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