Cancer BiologyCancer DiscoveryPeer-reviewed
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma
Zhuxuan Li, Xueqian Zhuang, Chun‐Hao Pan…·Tuomas Tammela
This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.