Author

Yan Xiang Wu

GenentechORCID 0000-0002-8874-8886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:protein sequence· 1

Frequent Co-Authors

Andrew M. WatkinsiD· 2 shared Franziska SeegeriD· 2 shared Henri Dwyer· 2 shared Homa MohammadiPeyhaniiD· 2 shared Imee SinhaiD· 2 shared Jack J. BeversiD· 2 shared Joseph KleinhenziD· 2 shared Karina Zadorozhny· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Andrew M. WatkinsORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintNov 12, 2025

CDR Conformation Aware Antibody Sequence Design with ConformAb

Imee Sinha, Samuel Stanton, Stephen P. Lillington…·Simon P. Kelow

ConformAb designs antibody sequences that maintain CDR canonical conformations, improving binding affinity without target-specific data.

1 citation

protein sequencedeep learning

𝕏 PostBluesky

Molecular BiologyMethodsPeer-reviewedMay 21, 2025

Enhancing RNA Delivery: Practical Insights into NeoLNP Transfection Reagent

Xiaobao Chen, Yan Xiang Wu, Li Liu, Wei Wang

This study evaluates the NeoLNP RNA Transfection Kit, identifying optimal parameters for transfection efficiency and providing practical guidelines for RNA delivery.

DOI 10.1016/j.ymeth.2025.05.007

experimental assay

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BioengineeringbioRxivPreprintFeb 19, 2025

Lab-in-the-loop therapeutic antibody design with deep learning

Nathan C. Frey, Isidro Hötzel, Samuel Stanton…·Vladimir Gligorijević

This paper introduces a machine learning framework for therapeutic antibody design that integrates computational methods with experimental validation, resulting in significantly improved binding affinity for multiple targets.

28 citations

machine learning (classical)drug response / drug discovery

𝕏 PostBluesky