Cell BiologyMolecular CellPeer-reviewed
Autophagy preferentially degrades non-fibrillar polyQ aggregates
Dorothy Yanling Zhao, Felix J.B. Bäuerlein, Itika Saha…·Florian Wilfling
This study shows autophagosomes preferentially degrade non-fibrillar polyQ aggregates by interacting with p62, while amyloid fibrils evade clearance due to their non-deformable structure.
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