Billy T. Lau

Clonalscope detects cancer subclones using DNA copy number data from single-cell and spatial omic sequencing, identifying spatially segregated subclones and validating them with matched scDNA-seq data.

This study analyzes DNA fragmentation and methylation in CSF-derived cfDNA from NSCLC-BMET patients and finds distinct patterns compared to controls and plasma-derived cfDNA.

This paper introduces MDRAM, a DNA-based random access memory system that enables efficient and scalable readouts using nanopore sequencing and magnetic bead conjugation.

The paper develops a nanopore sequencing strategy to measure cfDNA methylomes in cancer patients, enabling longitudinal monitoring during treatment.

The paper develops Longcell, a statistical framework for accurate isoform quantification in single cell and spatial long-read sequencing data, revealing intra-cell splicing heterogeneity and validating regulatory targets.

This study develops a single-cell method using nanopore sequencing to identify somatic mutations and gene rearrangements in cancer cells and integrates these with transcriptomes.

The paper develops a single-cell CRISPR base editor method to engineer and assess the transcriptional impact of cancer mutations in cell lines.

The paper integrates scDNA-seq and scRNA-seq data to characterize subclonal architecture and pathway activity in gastric and colorectal cancers.

The paper develops a single-cell method combining CRISPR edits and long-read sequencing to characterize transcript isoforms and confirm genomic edits at single-cell resolution.

Alleloscope analyzes allele-specific copy number and chromatin accessibility in single-cell cancer data, revealing complex copy number events and their role in intratumor heterogeneity.

The paper combines single cell DNA-Seq and RNA-Seq in gastric cancer to reveal subclonal genomic instability and gene expression patterns, showing evidence of tumor evolution.

The paper identifies ATG7 as a genetic risk factor for cholangiocarcinoma through germline mutations and population studies, linking autophagy dysfunction to cancer development.