Pierre Savatier

This study shows Netrin-1 supports naive pluripotency in hESCs by modulating epigenetic and signaling pathways, with effects dependent on culture conditions.

The paper identifies a ligand/receptor trafficking clock in pluripotent stem cells that regulates self-renewal and abscission dynamics through cyclic turnover of Netrin-1 and its receptors.

The paper identifies Asgard, a STAT3-regulated lncRNA, which controls microRNA biogenesis and sequestration to maintain naive pluripotency in mouse embryonic stem cells.

This study identifies KLF2, ERAS, and PRMT6 as factors enabling rabbit PSCs to generate chimeras by acquiring naive pluripotency and specific transcriptomic features.

This study identifies novel regulators of human naive pluripotency using a genetic switch that activates STAT3 and JAK signaling, revealing key genes and mechanisms involved in reprogramming.

The paper examines how XIST regulatory networks evolve in primates, showing extensive diversification and the role of transposons and enhancers in different species.

This study maps the transcriptomic, epigenetic, and metabolic changes in rabbit preimplantation embryos, identifying novel markers of naive pluripotency and similarities to human and primate embryos.

This study shows that grafts of neural precursors reverse cognitive and motor symptoms in a non-human primate model of Parkinson's disease.