Joe Ryan Delaney

This study shows that loss of metallothionein (MT) in cancer cells increases mutations by impairing DNA repair and causing metabolic imbalance.

This study links PIWIL2 downregulation in colon cancer to increased transposon activity and pro-tumorigenic phenotypes through bioinformatic and cell-based analyses.

This study identifies HSF1 and MYC co-amplification in ovarian cancer and shows that targeting PLK1 is more effective in these cells, suggesting a potential precision medicine approach.

This paper shows that combining MYC and p53-R270H mutations in a mouse model generates high-grade serous ovarian and uterine serous carcinomas with human-like genetic and transcriptomic features.

The paper introduces SWAN, a tool to identify oncogenic drivers in solid tumors by analyzing copy-number alterations, RNA expression, and mutations through pathway-network analysis.