Qi Shen

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

This study optimizes an AAV vector for efficient gene delivery to epidermal keratinocytes in vitro and in vivo by engineering capsid and promoter components.

The paper introduces a DNA-origami NanoTrap to study diffusion barriers formed by FG-nups and finds that motif type, density, and arrangement are critical for barrier effectiveness.

This study identifies Nsp1 as a key pathogenicity factor of SARS-CoV-2 that redirects host translation machinery to viral RNA by inhibiting cellular protein synthesis and altering gene expression programs.